Joylife Nutripharma Inc
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Chondroitin Sulfate is a naturally occurring sulfated glycosaminoglycan, typically sourced from bovine, porcine, or marine cartilage through advanced enzymatic extraction and purification technologies to ensure high purity, consistent molecular weight, and excellent bioavailability. As a critical structural component of the extracellular matrix, it plays an essential role in maintaining cartilage integrity by attracting and retaining water, promoting elasticity, and inhibiting the enzymes that degrade joint tissue. In nutritional and pharmaceutical applications, it is widely utilized for supporting joint health, reducing inflammation, alleviating osteoarthritis symptoms, and improving mobility. Its synergistic effect when combined with glucosamine and MSM makes it a cornerstone ingredient in premium joint health formulations, dietary supplements, and functional foods targeting long-term musculoskeletal wellness and cartilage protection.
Product Type and Application of Chondroitin Sulfate
| Source | Product Type (by Chemical Structure) | Characteristics | Application Area | Specific Uses & Reasons |
| Terrestrial Animals (Pig, Bovine, Poultry) | Mainly CSA (Sulfation at C-4) | High content, well-researched, the standard raw material for traditional pharmaceutical production. | Medical Field (Pharmaceutical Grade) | Treatment of osteoarthritis, ophthalmic adjuvant. Because its structure and purity are most stable, it meets pharmacopoeia standards (e.g., USP, EP, ChP) and has the longest history of clinical use and safety records. |
| High safety, controllable source, suitable for large-scale standardized production. | Health Food (Dietary Supplements) | Joint health supplements (often combined with Glucosamine). High consumer recognition, relatively controllable raw material costs, the most common type in the global market. | ||
| Marine Animals (Shark, Squid, Fish Bone) | Mainly CSC (Sulfation at C-6) | Structural uniqueness, containing disulfated disaccharides (e.g., CSD, CSE) less common in other sources. | High-End Dietary Supplements | Targeted joint needs. Often marketed as "Deep Sea/Shark Chondroitin" to attract consumers seeking natural, unique sources. |
| High molecular weight, good water retention. | Cosmetics/Skincare | Moisturizing, anti-wrinkle, repair. Its excellent moisturizing properties and ability to promote cell growth are utilized in high-end serums, masks, and eye drops. |
Below is a Sample Specification of Chondroitin Sulfate including main key info，
if need full content COA or specification please contact us by email.
| Test Items | USP | EP |
| Appearance | White or almost white, hygroscopic powder. | White or almost white, hygroscopic powder. |
| Identification | (1) infrared absorption <197k> (2) a solution containing 0.5 g in 10 ml of water meets the requirements of the test for sodium <191>. | (A) infrared absorption (2.2.24) (B) gives reaction (b) of sodium (2.3.1) (C) the principal band in the electropherogram obtained with the test solution is similar in position to that obtained with reference solution (a) |
| Clarity and color of solution | Its absorbance is not greater than 0.35. | / |
| Specific rotation <781s> | -20 °~ -30.0° | -20 °~ -30.0° |
| Microbial enumeration <2021> | The total bacterial count does not exceed 1000 cfu / g, and the total combined molds and yeasts count does not exceed 100 cfu / g. It meets the requirements of the tests for absence of Salmonella species, and Escherichia coli. | Total viable aerobic count (2.6.12) not more than 103 micro-organisms per gram. It complies with the tests for Staphylococus aureus, Pseudomonas aeruginosa, Escherichia coli, Salmonella and Enterobacteria and certain other gram-negative bacteria (2.6.13). |
| pH <791> | 5.5 ~ 7.5 in a solution (1 in 100) | 5.5~7.5 |
| Loss on drying <731> | Not more than 10.0% | not more than 12.0% |
| Residue on ignition <281> | 20.0% ~ 30.0% | / |
| Heavy metals, Method II <231> | Not more than 0.002%. | not more than 20 ppm |
| Electrophoretic purity <726> | Any individual impurity: not more than 2%. | Any individual impurity: not more than 2% |
| Limit of protein | Not more than 6.0% | not more than 3.0% |
| Content of chondroitin sulfate sodium | 90.0%~105.0% | 95% ~ 105% |
